Sahar Swidan, Pharm.D.

Sahar Swidan, Pharm.D.

BCPS, ABAAHP, FAARFM, FACA

Caffeine is a stimulant…for hair growth?

Did you know that CAFFEINE can help with Hair Growth? You thought it was only good at waking you UP.¬†ūüėČ

Alopecia is a problem that affects almost 50% of men and women also. Various causative agents are at play here but providing a topical solution that has multi-mechanism of action may help better combat the problem.

An Open-Label Randomized Multi-center Study Assessing the Non-inferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia. (Oct 2017)

Objective: To establish the non-inferiority of a caffeine-based liquid compared to minoxidil in the treatment of androgenic alopecia.

Design: This randomized, open-label trial enrolled 210 subjects with androgenic alopecia and randomized them to either the caffeine or minoxidil treatment groups. The change in proportion of anagen hairs after 6 months of treatment was the primary outcome.

Treatment: The caffeine treatment was a 0.2% caffeine solution, of which 2 mL were applied twice daily. The minoxidil used was 5% minoxidil solution, of which 1 mL was applied twice daily.

Results: Both treatments resulted in improved anagen ratios. The caffeine group had an anagen improvement of 10.59%, while the minoxidil showed a mean improvement of 11.68%. This difference was not statistically significant.

Conclusion: Topical treatment with 0.2% caffeine solution is not inferior to topical minoxidil 5% for treating androgenic alopecia.

Study: An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia. (Oct 2017)

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