Sahar Swidan, Pharm.D.

Sahar Swidan, Pharm.D.


Topical Cetirizine can be effective in the treatment of Hair Loss

“Androgenetic alopecia (AGA) is a common form of hair loss that affects males and females. Since AGA is multifactorial; addressing a few mechanisms of disease may be helpful in the treatment of this disorder.  Various treatments which showed clinical efficacy in past include minoxidil, finasteride, serenoa repens, and caffeine (it does more than just wake you up in the morning).  More recently, data on modulating prostaglandin PGF2a and the side effect of hypertrichosis caused clinical interest in the use of these analogues in the treatment of AGA.  Citirizine is a PGF2a analogue and its role was investigated with positive results in the treatment of this disorder.  A multi mechanism foam was formulated that incorporates many of the effective treatments into a single formulation including cetirizine.  Enjoy the study summary below.”

A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia. (Mar 2018)

Objective: To evaluate the efficacy of topical cetirizine in the treatment of androgenic alopecia.

Design: 85 patients, both male and female, were recruited for this pilot study. 67 were in the treatment group, while 18 served as controls. Total hair density, vellus hair density, terminal hair density, and diameter were assessed at baseline and after 6 months.

Treatment: Patients in the treatment group applied 1 mL of cetirizine 1% lotion once daily, while the placebo group applied a matching placebo.

Results: After 6 months, total hair density increased an average of 11% from baseline in the cetirizine group. Vellus hair density decreased 15% and terminal hair density increased 18% in the cetirizine group.

Conclusion: This pilot study suggests that treatment with topical cetirizine significantly improves androgenic alopecia.

Study: A preliminary study topical cetirizine in the therapeutic management of androgenetic alopecia. (Mar 2018)

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